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研究发现细胞套亡通过p53信号对抗上皮细胞基因组不稳定性新机制
作者: 中糖院 时间: 2020-11-12 09:33:57 浏览: 77

研究发现细胞套亡通过p53信号对抗上皮细胞基因组不稳定性新机制

yousifenlie(mitosis)shidongwuxibaodejibenfenliexingshi,gaiguochengshoudaoyangediaokong,yibaozhengchanshengzhengchangzidaixibao,jinerweichixibaodegengxinhuandaiherentideshengzhangfayu。dangyousifenliefashengyichangshi,tongchanghuijihuoxibaofangchuitizuzhuangjianchadian(spindle assemble checkpoint, sac)【1】,yanhuanyousifenlieyixiufuyichang。raner,yixiexibaohui“taoguo”gaijianshiguochengfenliechanshengfeizhengbeitizidaixibao(aneuploidy),daozhijiyinzushiwen,cujinxibaozhuanhuahezhongliujinzhan。jishifaxianbingqingchuzheixieyichangxibaoduiyuweichixibaojiyinzuwendinghezuzhiwentaizhiguanzhongyao。

2020nian10yue27ri,junshikexueyuanjunshiyixueyanjiuyuansunqiangyanjiuyuantuandui、jiefangjunzongyiyuanwangxiaoningjiaoshouheshoudouyikedaxuehuanghongyanjiaoshouhezuozailaopaiqikancell death & differentiationshangfabiaoletiwei"p53-dependent elimination of aneuploid mitotic offspring by entosis"dewenzhang【2】。

gaiyanjiushoucibaodaoleyizhongquanxindexibaoyousifenliejiance(mitotic surveillance)jizhi,ji,feizhengbeitizidaixibaokeyitongguozuanruxianglinxibao,xingchengcell-in-celljiegou,tongguojihuop53xinhaotonglu,youdaoleyizhongfeidiaowangxingxibaosiwang,taowang(entosis,xibaozailingyigexibaoneiderongmeititonglusiwang)。beixuanzeqingchu。

gaijizhichanshulexibaotaowang(entosis)deshengligongneng,faxianlexibaozhouqidiaokongzhiwaideyichangxibaoqingchuxinjizhi,tongshijieshilep53jiyinzaixibaoshuipingweichishangpiwentaiheyizhizhongliufashengdexintonglu;yifangmianfengfulexianyoudeyousifenliejiankongjizhi(mitotic surveillance)deneihan,zaicizhengmingxibaozuanxibao(cell-in-cell)suojubeideshengliyiyi。zhongyaodeshi,zheiyifaxianyeweimianyixitongdedingyitichulexindetiaozhan,chuantongmianyixuegainianrenwei,zhixingmianyigongnengdexibaozhuyaoshiyougusuifayuerlaidexibao(linbaxibao,danhexibaohelixibaodeng),zheiyifaxianbiaomingshangpixibaotongyangkeyizhixingleimianyigongneng,shixianzishenwending。

zhideyitideshixibaobaoneisiwangxianxiang(cell-in-cell death)shizhongguoxuezhewangxiaoningshangshijibashiniandaichufaxianhebiaoshude,yihuolingyurenke,cengbeithe scientistdafubaodao。guoqushinianjian,zhongguotuanduihaizaigailingyujieshihemingminglelianggexibaozuanxibaozhongyaoxianxiang,emperitosis(taodiao,muqianfaxiandejinyouliangzhongbutongbaoneisiwangtongluzhiyi)hein-cell infection(bingdudefeishoutiyilaixingxibaoganrantujing),juyoumingxiandeyinlingdiwei。jinnianhaifenbiezaifront cell dev biolzazhibaodaoleshougefuxingdiaokongentotic cell-in-celljiegouxingchengzhanfudanbaijiazufenzi—pcdh7【3】;zaicell reportszazhibaodaolediaokongentotic cell-in-celljiegouxingchengdedisangehexinyuanjian—zhelihuan【4】;zaisignal transduct target therzazhibaodaoqijinweizhiguojishangshougeduozhongxin、yangbenliangzuidadecell-in-cellfenxingfenxiyanjiu,faxianzhongliuxibaoneihuamianyixibaoxingchengdeyizhixingcell-in-celljiegoushirenyixiandaoguanaibuliangyuhouxiangguandeduliyuceyinsu,youqishiduinianqingdenvxingbingrenyucexiaolizuiqiang,yuanqiangyuchuantongdezuzhixuefenjihetnmfenqi【5】,bencifaxianshiduigailingyudeyouyicizhongyaogongxian。

xibaozuanxibaoyanjiujinshiniancaichengweiyigexinredian,zhongguodegongzuoriyishoudaoguojitongxingdeguanzhu,xiwangyeyinqiguoneitongxingdejinyibuguanzhu,baochiwoguozaigailingyudelingxiandiwei。

gailunwendiyizuozheweijunshikexueyuanjunshiyixueyanjiuyuanyuhuananligongdaxuelianhepeiyangshuoshiyanjiushengliangjianqing(muqianweifudandaxuezaiduboshisheng)、junshikexueyuanjunshiyixueyanjiuyuanzhuliyanjiuyuanniuzubiao、shoudouyikedaxuebeijingshijitanyiyuanboshiyanjiushengzhangbohejunshikexueyuanjunshiyixueyanjiuyuanshuoshiyanjiushengyuxiaochen。junshikexueyuanjunshiyixueyanjiuyuansunqiangyanjiuyuan、jiefangjunzongyiyuanwangxiaoningjiaoshou、shoudouyikedaxuebeijingshijitanyiyuanhuanghongyanjiaoshouweigailunwendegongtongtongxunzuozhe。

yanjiurenyuanliyongxibaodongtaichengxiangjishuzairenweizhuanhuashangpixibaomcf-10azhongguanchadao,bufenxibaoyousifenlieguochengzhonghuichuxianduanzandefenliezuzhi,suihoutaoyizuzhichenggongfenlie,tongshiqichanshengdezidaixibaohuizuanruxianglinxibaozhong,xingchengcell-in-celljiegou,jinersiwang。

jinyibuyanjiuxianshi: yousifenliezuzhidaozhidemqiyanzhangyifangmianshangdiaoxibaoneiderhoahuoxing,lingyifangmiandaozhidnasunshangdeleiji,jihuoxiayoudep53xinhaotonglu,tongguoshangdiaoxiaogdanbairnd3cujinrhoahuoxingzaixibaoneidejihuafenbu,tuidongxibaoneihuaxingchengcell-in-celljiegou。jinyibuliyongdongtaixianweichengxiang(time lapse microscopy)jieheyingguangyuanweizajiao(fish)jishuduineihuaxibaoransetishumufenxixianshi,neihuaxibaoweifeizhengbeitidezidaixibao,yizhicell-in-celljiegouxingchengjiedaodexibaotaowang(entosis)daozhifeizhengbeitixibaodexianzheleiji。(shengwugubioon.com)