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两篇论文: 首次揭示环状RNA在I型亚博手机app中的作用
作者: 中糖院 时间: 2020-11-13 08:20:40 浏览: 73

亚博手机appixingyaboshoujiapp(t1dm,yechengweiyidaosuyilaixingyaboshoujiapp)shiyizhongmanxingzishenmianyixingjibing,qilinchuangbiaoxiankeyifashengzaishengmingderenheshiqi;huanzheyidaosuchanshengjueduibuzu,xuzhongshenyilaiwailaiyidaosuzhiliao。genju2019nianguojiyaboshoujiapplianmeng(international diabetes federation,idf)fabiaodedijiubanshijieyaboshoujiappditu,t1dmfabinglvchengzhujianzengzhangdequshi,qizhong10-14suihuanzheshifabinglvzuigaodequnti。2010-2013nian,woguoshoucikaizhanlet1dmdengjizhuceyanjiu,yu20nianqiandiamonddiaochajieguoxiangbi,15suiyixiaertongnianfabinglvcong0.51shangshengdao1.93/10wanrennian,zengzhangyue3.8bei。t1dm yanzhongyingxianglehuanzhedeshenghuozhiliang,shihuanzhemianlinzheduoqiguangongnengshouleidefengxianhechenzhongdezhiliaofudan。

亚博手机appzait1dmdefabingguochengzhong,jushixibaoshizuizaojinrunyidaodemianyixibaozhiyi,tishijushixibaozait1dmfabingguochengzhongfahuizhezhongyaozuoyong。huanzhuangrna (circular rna,circrna)shiyileijingfanxiangjianjiehou、you3'moduanhe5'moduangongjiajiehexingchengdehuanzhuangfeibianmarnafenzi。jinnianlai,circrnayichengweijiyinzuzhongdiaokongjiyinbiaodadeyanjiuxinredian。ranermuqiancircrnaduijushixibaohuohuadeyingxiangjizait1dmzhongdezuoyongbuqingchu。jinri,yaboshoujiappzhouyufengtuanduifenbiezaitheranosticszazhihefrontiers in immunologyzazhifabiaoletiwei“circular rna circppm1f modulates m1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus”,he“hsa_circ_0060450 negatively regulates type i interferon-induced inflammation by serving as mir-199a-5p sponge in type 1 diabetes mellitus” dewenzhang,shoucijieshilecircrnazaiertongixingyaboshoujiappzhongdezuoyonghediaokongjizhi。

亚博手机appzaitheranosticslunwenzhong,yanjiurenyuanfaxian: (1)duiertongt1dmhuanzhehezhengchangertongwaizhouxuedangehexibao(pbmc)jinxinghuanzhuangrnaxinpianbiaodapu(gong88371tiaocircrna)fenxihou,gongyou58gehuanzhuangrnachengxianchuchayibiaodadequshi。qizhonglaiyuanyuppm1fjiyinwaixianzidehuanzhuangrna circppm1fzait1dmhuanzhezhongmingxiangaobiaoda,bingqiecircppm1fdebiaodashuipingyut1dmhuanzhexueqingzhongyanzhengyinziil-6,il-1βhetnf-αdebiaodashuipingchengzhengxiangguan。(2)tongguofenlirenwaizhouxuepbmczhongdet、byijidanhexibao,faxiancircppm1fzhuyaozaidanhexibaozhongbiaoda。jinyibudetiwaigongnengyanjiufaxian,zairendedanhexibaothp1xibaoxilaiyuandejushixibaozhong,qiaodicircppm1fnengyizhilps-tlr4-nf-κbxinhaotongludejihuo;xiangfan,guobiaodacircppm1fnengcujinlps-tlr4-nf-κbxinhaotongludejihuo,biaomingcircppm1fnengcujinm1xingjushixibaohuohua。(3)jizhiyanjiubiaoming: circppm1fzhuyaodingweiyuxibaohe,tongguoyuqimubenjiyinppm1fjingzhengxingjiehehurdanbai,jianshaolehuryuppm1fdejiehe,daozhippm1fzheiyidanbailinsuanmeidefanyinenglixiajiang,congercujinlep65delinsuanhuajinf-κbtongludehuohua。(4)jinyibufaxiant1dmhuanzhezhongeif4a3biaodaxiadiao,fusbiaodashangdiao,bingqiecircppm1fdeshengchengshoudaoeif4a3hefusdexiediaodiaokong。(5)jushixibaoyuyidaoxibaotiwaigongpeiyangjieguobiaoming,circppm1fjiedaodem1xingjushixibaohuohuaketongguocujinyidaoβxibaomapktonglujihuocongercujinqidiaowangguocheng。(6)zuihou,liyonglianniaojunsu(streptozocin,stz)youdaodet1dmxiaoshumoxing,zuozhefaxiantineiguobiaodacircppm1fjiazhongleyaboshoujiappxiaoshudelinchuangbiaoxingheyidaosunshang;jinyibuyanjiubiaomingcircppm1fnenggoucujinm1xingjushixibaozaiyidaodejinrun,jihuoyixianzuzhimapkhestat3xinhaotonglu,shiyixianxibaofashengdiaowang、yanghuayingjisunshangheyanzhengfanying。

亚博手机appjuxi,fudandaxuefushuerkeyiyuanboshiyanjiushengzhangcaiyan、zhuliyanjiuyuanhanxiao、fudandaxueshengwuyixueyanjiuyuanboshiyanjiushengyanglanheerkeyiyuanfujingrongzhuzhiyishiweiwenzhangdegongtongdiyizuozhe;fudandaxueshengwuyixueyanjiuyuan/fushuerkeyiyuanzhouyufengyanjiuyuanweiwenzhangdetongxunzuozhe。fudandaxuefushuerkeyiyuanneifenmiyichuandaixiekezhuzhiyishisunchengjun、fuzhurenyishiluwei、zhurenyishiluofeihongyeduibenyanjiuzuochulezhongyaogongxian。

zailingyipianyanjiuzhong,zuozhefenxilelingwaiyitiaozait1dmbingrenpbmcsyangbenzhonggaobiaodadecircrna hsa_circ_0060450degongnenghezuoyongjizhi。houxudeyanjiubiaoming: xibaozhizhongdehsa_circ_0060450kezuoweiyizhonghaimianzhuangxifutixifumir-199a-5p,shibaojiangzhongyoulidemir-199a-5pjianshao。ermir-199a-5pketongguobaxiangyizhilinsuanhuameishp-2debiaodacongercujinyanzhengfanying。yinci,hsa_circ_0060450ketongguozengjiashp-2biaodaeryizhiixingganraosuduijushixibaodehuohuaheyidaoxibaodeyanzhengsunshang。jieshihsa_circ_0060450youkenengchengweit1dmzhiliaodefenziyaowu。

亚博手机appjuxi,fudandaxueshengwuyixueyanjiuyuanboshiyanjiushengyanglan、fudandaxuefushuerkeyiyuanzhuliyanjiuyuanhanxiao、boshiyanjiushengzhangcaiyanheneifenmiyichuandaixiekesunchengjunzhuzhiyishiweiwenzhangdegongtongdiyizuozhe;fudandaxuefushuerkeyiyuanfujingrongzhuzhiyishiheshengwuyixueyanjiuyuan/erkeyiyuanzhouyufengyanjiuyuanweiwenzhangdetongxunzuozhe。fudandaxuefushuerkeyiyuanneifenmiyichuandaixiekefuzhurenyishiluwei、zhurenyishiluofeihongyeduibenyanjiuzuochulezhongyaogongxian。

zongshang,liangpianyanjiufenbiejieshilefahuicuyanzuoyongdecircppm1fhefahuiyiyanzuoyongdehsa_circ_0060450tongguoxibaohehexibaozhiliangzhongbutongdezuoyongjizhiyingxiangyixianzuzhizhongm1xingjushixibaohuohuajinercanyut1dmfashengfazhandejili。congduojiaoduchanminglecircrnazait1dmzhongdegongnenghefenzijizhi,weijinhout1dmdejichuyanjiuhelinchuangzhiliaotigonglexindesilu。

yuanwenlianjie:

http://doi.org/10.3389/fimmu.2020.576903